We commend the study by Santos-Sanz and colleagues in December JADA (Santos-Sanz L,
Toledano-Serrabona J, Gay-Escoda C. Safety and Efficacy of 4% Articaine in Mandibular
Third-Molar Extraction: A Systematic Review and Meta-analysis of Randomized Clinical
Trials. JADA. 2020;151:912-923) that took a closer look at the safety and efficacy of 4% articaine
while extracting a mandibular third molar, albeit with few concerns.
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Factors predictive of the onset and duration of action of local anesthesia in mandibular third-molar surgery: a prospective study.
Eur J Oral Sci. 2018; 126: 110-117
Articaine and mepivacaine efficacy in postoperative analgesia for lower third molar removal: a double-blind, randomized, crossover study.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 102: 169-174
4% lidocaine versus 4% articaine for inferior alveolar nerve block in impacted lower third molar surgery.
J Dent Anesth Pain Med. 2017; 17: 29-35
Introduction to meta-analysis by Michael Borenstein, Larry V. Hedges, Julian P.T. Higgins, Hannah R. Rothstein.
Int Stat Rev. 2009; 77: 478-479
Methodological issues in a meta-analysis.
Curr Med Res Opin. 2017; 33: 1813
Outlier and influence diagnostics for meta-analysis.
Res Synth Methods. 2010; 1: 112-125
© 2021 Published by Elsevier Inc. on behalf of the American Dental Association.
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