Abstract
Background
Ligneous periodontitis is a rare periodontal condition characterized by pseudomembranous
enlargement of gingiva with marked impairment in fibrinolysis. The term ligneous is
defined as made of, consisting of, or resembling wood; woody. Few cases of ligneous
disease have been described in the literature.
Case Description
The authors describe the case of a 32-year-old woman with autism spectrum disorder
who had multiple, ulcerated, erythematous, nodular enlargements of the maxillary and
mandibular anterior gingiva. Histopathologic examination revealed extensive fibrinous
deposits in the submucosa. The patient’s laboratory test results showed plasminogen
activity of less than 5%. The patient received a final diagnosis of ligneous periodontitis
on the basis of histopathologic features and laboratory findings. Recurrence was not
noted until 3 months after excision.
Practical Implications
Autism spectrum disorders can be associated with ligneous diseases. Because ligneous
disease is a lifelong systemic disease affecting multiple systems, early diagnosis
is essential to prevent infections and additional periodontal destruction.
Key Words
Abbreviation Key:
ASD (Autism spectrum disorder), PLG (Plasminogen), tPA (Tissue-type plasminogen activator)
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Biography
Dr. Krishnan is a senior lecturer, Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India.
Biography
Dr. Ramani is a professor and department head, Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India.
Biography
Dr. Pandiar is an associate professor, Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India.
Biography
Dr. Y is a postgraduate student, Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India.
Article info
Publication history
Published online: January 23, 2023
Publication stage
In Press Corrected Proof
Footnotes
Disclosures. None of the authors reported any disclosures.
Identification
DOI: https://doi.org/10.1016/j.adaj.2022.12.005
Copyright
© 2022 American Dental Association. All rights reserved.
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