Home Dental Imbalance in gum bacteria linked to Alzheimer’s disease biomarker — ScienceDaily

Imbalance in gum bacteria linked to Alzheimer’s disease biomarker — ScienceDaily

by adminjay


Older adults with more harmful than healthy bacteria in their gums are more likely to have evidence for amyloid beta — a key biomarker for Alzheimer’s disease — in their cerebrospinal fluid (CSF), according to new research from NYU College of Dentistry and Weill Cornell Medicine. However, this imbalance in oral bacteria was not associated with another Alzheimer’s biomarker called tau.

The study, published in the journal Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, adds to the growing evidence of a connection between periodontal disease (gum disease) and Alzheimer’s. Periodontal disease — which affects 70 percent of adults 65 and older, according to CDC estimates — is characterized by chronic and systemic inflammation, with pockets between the teeth and gums enlarging and harboring bacteria.

“To our knowledge, this is the first study showing an association between the imbalanced bacterial community found under the gumline and a CSF biomarker of Alzheimer’s disease in cognitively normal older adults,” said Angela Kamer, DDS, PhD, associate professor of periodontology and implant dentistry at NYU College of Dentistry and the study’s lead author. “The mouth is home to both harmful bacteria that promote inflammation and healthy, protective bacteria. We found that having evidence for brain amyloid was associated with increased harmful and decreased beneficial bacteria.”

Alzheimer’s disease is characterized by two hallmark proteins in the brain: amyloid beta, which clumps together to form plaques and is believed to be the first protein deposited in the brain as Alzheimer’s develops, and tau, which builds up in nerve cells and forms tangles.

“The mechanisms by which levels of brain amyloid accumulate and are associated with Alzheimer’s pathology are complex and only partially understood. The present study adds support to the understanding that proinflammatory diseases disrupt the clearance of amyloid from the brain, as retention of amyloid in the brain can be estimated from CSF levels,” said the study’s senior author Mony J. de Leon, EdD, professor of neuroscience in radiology and director of the Brain Health Imaging Institute at Weill Cornell Medicine. “Amyloid changes are often observed decades before tau pathology or the symptoms of Alzheimer’s disease are detected.”

The researchers studied 48 healthy, cognitively normal adults ages 65 and older. Participants underwent oral examinations to collect bacterial samples from under the gumline, and lumbar puncture was used to obtain CSF in order to determine the levels of amyloid beta and tau. To estimate the brain’s expression of Alzheimer’s proteins, the researchers looked for lower levels of amyloid beta (which translate to higher brain amyloid levels) and higher levels of tau (which reflect higher brain tangle accumulations) in the CSF.

Analyzing the bacterial DNA of the samples taken from beneath the gumline under the guidance of NYU College of Dentistry microbiologist Deepak Saxena, PhD, the researchers quantified bacteria known to be harmful to oral health (e.g. Prevotella, Porphyromonas, Fretibacterium) and pro-oral health bacteria (e.g. Corynebacterium, Actinomyces, Capnocytophaga).

The results showed that individuals with an imbalance in bacteria, with a ratio favoring harmful to healthy bacteria, were more likely to have the Alzheimer’s signature of reduced CSF amyloid levels. The researchers hypothesize that because high levels of healthy bacteria help maintain bacterial balance and decrease inflammation, they may be protective against Alzheimer’s.

“Our results show the importance of the overall oral microbiome — not only of the role of ‘bad’ bacteria, but also ‘good’ bacteria — in modulating amyloid levels,” said Kamer. “These findings suggest that multiple oral bacteria are involved in the expression of amyloid lesions.”

The researchers did not find an association between gum bacteria and tau levels in this study, so it remains unknown whether tau lesions will develop later or if the subjects will develop the symptoms of Alzheimer’s. The researchers plan to conduct a longitudinal study and a clinical trial to test if improving gum health — through “deep cleanings” to remove deposits of plaque and tartar from under the gumline — can modify brain amyloid and prevent Alzheimer’s disease.

Story Source:

Materials provided by New York University. Note: Content may be edited for style and length.



Source link

Related Articles

29 comments

Szlepw August 5, 2021 - 9:46 am

tadalafil 5 mg tablet price – cialis generic brand top 10 pharmacy websites

Reply
Jeirfz August 5, 2021 - 3:20 pm

buy cialis in nz – 100 dollars cialis cheap black cialis

Reply
Jyxsxc August 7, 2021 - 7:24 am

ivermectin pills canada – covid ivermectin ivermectin 3mg tabs

Reply
Lnuqtc August 8, 2021 - 7:36 pm

best online casino – doubleu casino online casino real money casino games

Reply
Ullykf August 10, 2021 - 7:35 am

low cost ed pills – over the counter erectile dysfunction medication best ed pills non prescription

Reply
Xzjbdd August 11, 2021 - 6:19 pm

generic over the counter prednisone – prednisone 60 mg tablets can you buy prednisone over the counter in usa

Reply
Eqesgh August 13, 2021 - 5:06 am

order viagra online without a preion – sildenafil 100mg australia viagra usa online

Reply
Geeuiv August 14, 2021 - 7:05 pm

cialis cheap online – Best cialis price online cialis from canada

Reply
Vcqrvc August 16, 2021 - 8:22 am

ivermectin 0.2mg – cost of stromectol pill buy ivermectin usa

Reply
Pofias August 18, 2021 - 4:38 am

best pill for ed – natural remedies for ed problems compare ed drugs

Reply
Acsqmm August 22, 2021 - 2:01 am

ventolin price canada – onventolinp.com ventolin generic

Reply
Uqmonh August 23, 2021 - 12:00 pm

can i buy cytotec over the counter in south africa – cytotec online order cytotec canada

Reply
Kpbpjw August 24, 2021 - 10:45 pm

doxycycline 200mg – buy doxycycline online no prescription doxycycline generic cost

Reply
Jdfwvl August 26, 2021 - 10:29 am

neurontin 50 mg – ordering neurontin online synthroid 0.088

Reply
Bcwcxn August 27, 2021 - 11:57 pm

best viagra tablet – where to buy viagra pharmacy sildenafil 20 mg online pharmacy

Reply
Pvtyjn August 29, 2021 - 7:37 am

tadalafil buy online india – cialis best price uk low cost cialis

Reply
Nommqn August 30, 2021 - 11:05 am

buy viagra cialis vardenafil online – generic vardenafil vs generic it vardenafil

Reply
Mkvcix September 1, 2021 - 12:08 am

stromectol oral – stromectol us

Reply
Tbgbdj September 2, 2021 - 1:20 am

otc prednisone – 60 mg prednisone prednisone 20mg online without prescription

Reply
Qbugtp September 3, 2021 - 8:09 am

order accutane on line no prescription – how much is accutane in canada accutane medicine

Reply
Qwkvlg September 4, 2021 - 8:31 pm

buy amoxicilin 500 mg online canada – amoxil amoxicillin sales worldwide

Reply
Qlhsbc September 6, 2021 - 2:15 am

how much is methylprednisolone – rx medrol lyrica 75 mg price south africa

Reply
Rncnha September 7, 2021 - 6:08 am

buy essay now – essays on the help academic writing terms

Reply
Qoeqfw September 8, 2021 - 2:19 pm

female viagra pills price – Buy viagra cheap buy cheap viagra online canada

Reply
Izqmho September 9, 2021 - 10:20 pm

canadian pharmacy 365 – Real cialis online where to buy cialis otc

Reply
Qvuqyt September 12, 2021 - 7:27 am

stromectol for sale – stromectol cost canada ivermectin eye drops

Reply
Xchwxy September 13, 2021 - 9:26 am

prednisone buy cheap – prednisone 20 mg buy online order prednisone 40mg

Reply
Xfnxla September 14, 2021 - 2:54 pm

furosemide tablets uk – buy lasix without a prescription furosemide 40 mg tablet price

Reply
Eslpux September 15, 2021 - 7:56 pm

ventolin generic price – ventolin nebules albuterol nebulizer

Reply

Leave a Comment