Bodic, F., Hamel, L., Lerouxel, E., Basle, M. F. & Chappard, D. Bone loss and teeth. Joint, bone, spine: revue du rhumatisme 72, 215–221, https://doi.org/10.1016/j.jbspin.2004.03.007 (2005).
Kawata, T., Yoda, N., Kawaguchi, T., Kuriyagawa, T. & Sasaki, K. Behaviours of three-dimensional compressive and tensile forces exerted on a tooth during function. Journal of oral rehabilitation 34, 259–266, https://doi.org/10.1111/j.1365-2842.2007.01681.x (2007).
Viecilli, R. F., Katona, T. R., Chen, J., Hartsfield, J. K. Jr. & Roberts, W. E. Three-dimensional mechanical environment of orthodontic tooth movement and root resorption. American journal of orthodontics and dentofacial orthopedics: official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 133, 791 e711–726, https://doi.org/10.1016/j.ajodo.2007.11.023 (2008).
Mabuchi, R., Matsuzaka, K. & Shimono, M. Cell proliferation and cell death in periodontal ligaments during orthodontic tooth movement. Journal of periodontal research 37, 118–124 (2002).
Meikle, M. C. The tissue, cellular, and molecular regulation of orthodontic tooth movement: 100 years after Carl Sandstedt. European journal of orthodontics 28, 221–240, https://doi.org/10.1093/ejo/cjl001 (2006).
Krishnan, V. & Davidovitch, Z. Cellular, molecular, and tissue-level reactions to orthodontic force. American journal of orthodontics and dentofacial orthopedics: official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 129, 469 e461–432, https://doi.org/10.1016/j.ajodo.2005.10.007 (2006).
Zhang, L. et al. Mechanical stress regulates osteogenic differentiation and RANKL/OPG ratio in periodontal ligament stem cells by the Wnt/beta-catenin pathway. Biochimica et biophysica acta 1860, 2211–2219, https://doi.org/10.1016/j.bbagen.2016.05.003 (2016).
Garlet, T. P., Coelho, U., Silva, J. S. & Garlet, G. P. Cytokine expression pattern in compression and tension sides of the periodontal ligament during orthodontic tooth movement in humans. European journal of oral sciences 115, 355–362, https://doi.org/10.1111/j.1600-0722.2007.00469.x (2007).
Andrade, I. Jr., Taddei, S. R. A. & Souza, P. E. A. Inflammation and Tooth Movement: The Role of Cytokines, Chemokines, and Growth Factors. Seminars in Orthodontics 18, 257–269, https://doi.org/10.1053/j.sodo.2012.06.004 (2012).
Basdra, E. K. & Komposch, G. Osteoblast-like properties of human periodontal ligament cells: an in vitro analysis. European journal of orthodontics 19, 615–621, https://doi.org/10.1093/ejo/19.6.615 (1997).
Lekic, P., Rojas, J., Birek, C., Tenenbaum, H. & McCulloch, C. A. Phenotypic comparison of periodontal ligament cells in vivo and in vitro. Journal of periodontal research 36, 71–79 (2001).
Li, M., Zhang, C. & Yang, Y. Effects of mechanical forces on osteogenesis and osteoclastogenesis in human periodontal ligament fibroblasts: A systematic review of in vitro studies. Bone & joint research 8, 19–31, https://doi.org/10.1302/2046-3758.81.BJR-2018-0060.R1 (2019).
Sokos, D., Everts, V. & de Vries, T. J. Role of periodontal ligament fibroblasts in osteoclastogenesis: a review. Journal of periodontal research 50, 152–159, https://doi.org/10.1111/jre.12197 (2015).
Marchesan, J. T., Scanlon, C. S., Soehren, S., Matsuo, M. & Kapila, Y. L. Implications of cultured periodontal ligament cells for the clinical and experimental setting: a review. Archives of oral biology 56, 933–943, https://doi.org/10.1016/j.archoralbio.2011.03.003 (2011).
Li, I., Jacox, L. A., Little, S. H. & Ko, C. Orthodontic tooth movement: The biology and clinical implications. The Kaohsiung Journal of Medical Sciences 34, 207–214, https://doi.org/10.1016/j.kjms.2018.01.007 (2018).
Iglesias-Linares, A., Morford, L. A. & Hartsfield, J. K. Jr. Bone Density and Dental External Apical Root Resorption. Current osteoporosis reports 14, 292–309, https://doi.org/10.1007/s11914-016-0340-1 (2016).
Michelogiannakis, D. et al. Influence of nicotine on orthodontic tooth movement: A systematic review of experimental studies in rats. Archives of oral biology 93, 66–73, https://doi.org/10.1016/j.archoralbio.2018.05.016 (2018).
Fujita, Y. & Maki, K. High-fat diet-induced obesity triggers alveolar bone loss and spontaneous periodontal disease in growing mice. BMC obesity 3, 1, https://doi.org/10.1186/s40608-016-0082-8 (2015).
Bootcov, M. R. et al. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proceedings of the National Academy of Sciences of the United States of America 94, 11514–11519 (1997).
Breit, S. N. et al. The TGF-beta superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism. Growth factors 29, 187–195, https://doi.org/10.3109/08977194.2011.607137 (2011).
Chen, G., Deng, C. & Li, Y. P. TGF-beta and BMP signaling in osteoblast differentiation and bone formation. International journal of biological sciences 8, 272–288, https://doi.org/10.7150/ijbs.2929 (2012).
Wu, M., Chen, G. & Li, Y. P. TGF-beta and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease. Bone research 4, 16009, https://doi.org/10.1038/boneres.2016.9 (2016).
Bottner, M., Suter-Crazzolara, C., Schober, A. & Unsicker, K. Expression of a novel member of the TGF-beta superfamily, growth/differentiation factor-15/macrophage-inhibiting cytokine-1 (GDF-15/MIC-1) in adult rat tissues. Cell and tissue research 297, 103–110 (1999).
Hsiao, E. C. et al. Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury. Molecular and cellular biology 20, 3742–3751 (2000).
Bauskin, A. R. et al. Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer. Cancer research 66, 4983–4986, https://doi.org/10.1158/0008-5472.CAN-05-4067 (2006).
Vanhara, P. et al. Growth/differentiation factor-15 inhibits differentiation into osteoclasts–a novel factor involved in control of osteoclast differentiation. Differentiation; research in biological diversity 78, 213–222, https://doi.org/10.1016/j.diff.2009.07.008 (2009).
Hinoi, E. et al. Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 27, 938–949, https://doi.org/10.1002/jbmr.1538 (2012).
Westhrin, M. et al. Growth differentiation factor 15 (GDF15) promotes osteoclast differentiation and inhibits osteoblast differentiation and high serum GDF15 levels are associated with multiple myeloma bone disease. Haematologica 100, e511–514, https://doi.org/10.3324/haematol.2015.124511 (2015).
Frank, D. et al. Gene expression pattern in biomechanically stretched cardiomyocytes: evidence for a stretch-specific gene program. Hypertension 51, 309–318, https://doi.org/10.1161/HYPERTENSIONAHA.107.098046 (2008).
De Jong, A. M. et al. Cyclical stretch induces structural changes in atrial myocytes. Journal of cellular and molecular medicine 17, 743–753, https://doi.org/10.1111/jcmm.12064 (2013).
Muralidharan, A. R., Maddala, R., Skiba, N. P. & Rao, P. V. Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork. Cells. Investigative ophthalmology & visual science 57, 6482–6495, https://doi.org/10.1167/iovs.16-20671 (2016).
Rys, J. P., Monteiro, D. A. & Alliston, T. Mechanobiology of TGFbeta signaling in the skeleton. Matrix biology: journal of the International Society for Matrix Biology 52–54, 413–425, https://doi.org/10.1016/j.matbio.2016.02.002 (2016).
Wang, J. H., Thampatty, B. P., Lin, J. S. & Im, H. J. Mechanoregulation of gene expression in fibroblasts. Gene 391, 1–15, https://doi.org/10.1016/j.gene.2007.01.014 (2007).
Langevin, H. M. et al. Fibroblast cytoskeletal remodeling induced by tissue stretch involves ATP signaling. Journal of cellular physiology 228, 1922–1926, https://doi.org/10.1002/jcp.24356 (2013).
Shim, J. W., Wise, D. A. & Elder, S. H. Effect of Cytoskeletal Disruption on Mechanotransduction of Hydrostatic Pressure by C3H10T1/2 Murine Fibroblasts. The open orthopaedics journal 2, 155–162, https://doi.org/10.2174/1874325000802010155 (2008).
Aw Yong, K. M. et al. Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis. Journal of cellular physiology 229, 362–373, https://doi.org/10.1002/jcp.24458 (2014).
Howard, P. S., Kucich, U., Taliwal, R. & Korostoff, J. M. Mechanical forces alter extracellular matrix synthesis by human periodontal ligament fibroblasts. Journal of periodontal research 33, 500–508 (1998).
Duarte, W. R. et al. Effects of mechanical stress on the mRNA expression of S100A4 and cytoskeletal components by periodontal ligament cells. Journal of medical and dental sciences 46, 117–122 (1999).
Li, S. et al. Maturation of growth differentiation factor 15 in human placental trophoblast cells depends on the interaction with Matrix Metalloproteinase-26. The Journal of clinical endocrinology and metabolism 99, E2277–2287, https://doi.org/10.1210/jc.2014-1598 (2014).
Abd El-Aziz, S. H., Endo, Y., Miyamaori, H., Takino, T. & Sato, H. Cleavage of growth differentiation factor 15 (GDF15) by membrane type 1-matrix metalloproteinase abrogates GDF15-mediated suppression of tumor cell growth. Cancer science 98, 1330–1335, https://doi.org/10.1111/j.1349-7006.2007.00547.x (2007).
Bildt, M. M., Bloemen, M., Kuijpers-Jagtman, A. M. & Von den Hoff, J. W. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in gingival crevicular fluid during orthodontic tooth movement. European journal of orthodontics 31, 529–535, https://doi.org/10.1093/ejo/cjn127 (2009).
Diercke, K., Sen, S., Kohl, A., Lux, C. J. & Erber, R. Compression-dependent up-regulation of ephrin-A2 in PDL fibroblasts attenuates osteogenesis. Journal of dental research 90, 1108–1115, https://doi.org/10.1177/0022034511413926 (2011).
Edfors, F. et al. Gene-specific correlation of RNA and protein levels in human cells and tissues. Molecular systems biology 12, 883, https://doi.org/10.15252/msb.20167144 (2016).
Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M. & Altman, D. G. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. Journal of pharmacology & pharmacotherapeutics 1, 94–99, https://doi.org/10.4103/0976-500X.72351 (2010).
Jager, A. et al. Soluble cytokine receptor treatment in experimental orthodontic tooth movement in the rat. European journal of orthodontics 27, 1–11, https://doi.org/10.1093/ejo/cjh089 (2005).
Ong, C. K., Walsh, L. J., Harbrow, D., Taverne, A. A. & Symons, A. L. Orthodontic tooth movement in the prednisolone-treated rat. The Angle orthodontist 70, 118–125, 10.1043/0003-3219(2000)070<0118:OTMITP>2.0.CO;2 (2000).
Kirschneck, C. et al. Valid gene expression normalization by RT-qPCR in studies on hPDL fibroblasts with focus on orthodontic tooth movement and periodontitis. Scientific reports 7, 14751, https://doi.org/10.1038/s41598-017-15281-0 (2017).
Untergasser, A. et al. Primer3–new capabilities and interfaces. Nucleic acids research 40, e115, https://doi.org/10.1093/nar/gks596 (2012).
Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402–408, https://doi.org/10.1006/meth.2001.1262 (2001).
Schindelin, J. et al. Fiji: an open-source platform for biological-image analysis. Nature methods 9, 676–682, https://doi.org/10.1038/nmeth.2019 (2012).