Use of calcium-containing bioactive desensitizers in dental bleaching

Tray bleaching status and insights.

J Esthet Restor Dent. 2021; 33: 27-38

• Reis A.
• da Silva L.M.
• Martins L.
• Loguercio A.

In-office tooth whitening.

Clin Dent Rev. 2018; 2: 1-8

Review of the mechanism of tooth whitening.

J Esthet Restor Dent. 2015; 27: 240-257

• Favoreto M.W.
• Hass V.
• Maran B.M.
• et al.

At-home nleaching with a novel carbamide peroxide polymeric nanoparticle gel: a multicenter randomized controlled trial.

Oper Dent. 2022; 47: 492-502

• Esteves L.M.B.
• dos Santos P.H.
• Fagundes T.C.
• et al.

Effect of bleaching gel volume on color change and postoperative sensitivity: a randomized clinical study.

Clin Oral Investig. 2022; 26: 2527-2536

• Carneiro T.S.
• Favoreto M.W.
• Bernardi L.G.
• et al.

Gingival irritation in patients submitted to at-home bleaching with different cutouts of the bleaching tray: a randomized, single-blind clinical trial.

Clin Oral Investig. 2022; 26: 4381-4390

• Donassollo S.H.
• Donassollo T.A.
• Coser S.
• et al.

Triple-blinded randomized clinical trial comparing efficacy and tooth sensitivity of in-office and at-home bleaching techniques.

J Appl Oral Sci. 2021; 29e20200794

• Meireles S.S.
• Santos M.E.
• Lustosa Í M.C.
• Leite E.L.L.

Effects of a reduced in-office bleaching protocol with 37.5% hydrogen peroxide on effectiveness and tooth sensitivity: a double-blind randomized clinical trial.

J Esthet Restor Dent. 2021; 33: 824-831

• Kothari S.
• Jum’ah A.A.
• Gray A.R.
• ML K.
• Yap M.
• Brunton P.A.

A randomized clinical trial investigating three vital tooth bleaching protocols and associated efficacy, effectiveness and participants’ satisfaction.

J Dent. 2020; 95103322

• Martini E.C.
• Favoreto M.W.
• Coppla F.M.
• Loguercio A.D.
• Reis A.

Evaluation of reservoirs in bleaching trays for at-home bleaching: a split-mouth single-blind randomized controlled equivalence trial.

J Appl Oral Sci. 2020; 28e20200332

• de Sá J.L.
• Silva J.S.
• Herkrath F.J.
• et al.

In-office bleaching with complete cervical third protection protocol: a split-mouth, double-blind, randomized clinical trial.

Am J Dent. 2021; 34: 281-285

• Parreiras S.O.
• Favoreto M.W.
• Cruz G.P.
• et al.

Initial and pulp chamber concentration of hydrogen peroxide using different bleaching products.

Braz Dent Sci. 2020; 23: 8

• Coppla F.M.
• Freire A.
• Bittencourt B.
• et al.

Influence of simplified, higher-concentrated sodium ascorbate application protocols on bond strength of bleached enamel.

J Clin Exp Dent. 2019; 11: e21-e26

• Coceska E.
• Gjorgievska E.
• Coleman N.J.
• et al.

Enamel alteration following tooth bleaching and remineralization.

J Microsc. 2016; 262: 232-244

• Acuña E.D.
• Parreiras S.O.
• Favoreto M.W.
• et al.

In-office bleaching with a commercial 40% hydrogen peroxide gel modified to have different pHs: color change, surface morphology, and penetration of hydrogen peroxide into the pulp chamber.

J Esthet Restor Dent. 2022; 34: 322-327

• Cavalli V.
• da Rosa D.A.
• da Silva D.P.
• et al.

Effects of experimental bleaching agents on the mineral content of sound and demineralized enamels.

J Appl Oral Sci. 2018; 26e20170589

• Jager D.H.
• Vieira A.M.
• Ligtenberg A.J.
• Bronkhorst E.
• Huysmans M.C.
• Vissink A.

Effect of salivary factors on the susceptibility of hydroxyapatite to early erosion.

Caries Res. 2011; 45: 532-537

• Sa Y.
• Sun L.
• Wang Z.
• et al.

Effects of two in-office bleaching agents with different pH on the structure of human enamel: an in situ and in vitro study.

Oper Dent. 2013; 38: 100-110

• Sa Y.
• Chen D.
• Liu Y.
• et al.

Effects of two in-office bleaching agents with different pH values on enamel surface structure and color: an in situ vs. in vitro study.

J Dent. 2012; 40: e26-34

• Parreiras S.O.
• Favoreto M.W.
• Lenz R.E.
• et al.

Effect of prior application of desensitizing agent on the teeth submitted to in-office bleaching.

Braz Dent J. 2020; 31: 236-243

• Kwon S.R.
• Dawson D.V.
• Wertz P.W.

Time course of potassium nitrate penetration into the pulp cavity and the effect of penetration levels on tooth whitening efficacy.

J Esthet Restor Dent. 2016; 28: S14-22

• Martini E.C.
• Favoreto M.W.
• Rezende M.
• de Geus J.L.
• Loguercio A.D.
• Reis A.

Topical application of a desensitizing agent containing potassium nitrate before dental bleaching: a systematic review and meta-analysis.

Clin Oral Investig. 2021; 25: 4311-4327

• Browning W.D.
• Cho S.D.
• Deschepper E.J.

Effect of a nano-hydroxyapatite paste on bleaching-related tooth sensitivity.

J Esthet Restor Dent. 2012; 24: 268-276

• de Araújo I.D.T.
• de Sousa Santos K.
• das Neves Peixoto T.V.O.
• Costa M.J.F.
• de Assunção I.V.
• Borges B.C.D.

The combined use of systemic analgesic/anti-inflammatory drugs and a bioactive topical desensitizer for reduced in-office bleaching sensitivity without jeopardizing the hydrogen peroxide efficacy: a randomized, triple blinded, split-mouth clinical trial.

Clin Oral Investig. 2021; 25: 6623-6632

• Mehta D.
• Jyothi S.
• Moogi P.
• Finger W.J.
• Sasaki K.

Novel treatment of in-office tooth bleaching sensitivity: a randomized, placebo-controlled clinical study.

J Esthet Restor Dent. 2018; 30: 254-258

• Oldoini G.
• Bruno A.
• Genovesi A.M.
• Parisi L.

Effects of amorphous calcium phosphate administration on dental sensitivity during in-office and at-home interventions.

Dent J (Basel). 2018; 6: 52

• Singh M.
• Mahajan P.
• Monga P.
• Mahajan S.
• Singla D.
• Kaur N.J.E.

Comparative evaluation of the effectiveness of sodium fluoride and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in treating postoperative sensitivity associated with in-office vital tooth bleaching: a clinical study.

Endontology. 2017; 29: 26-34

• Tawfik S.S.
• Khairy M.A.E.
• ElBaz M.A.E.J.F.

Evaluation of post-bleaching hypersensitivity using desensitizing agent before and/or after in-office bleaching: a randomized clinical trial.

F1000 Res. 2019; 8: 1762

Effect of CPP-ACP on efficacy and postoperative sensitivity associated with at-home vital tooth bleaching using 20% carbamide peroxide.

Clin Oral Investig. 2019; 23: 1555-1559

• Ubaldini A.
• Pascotto R.C.
• Sato F.
• Soares V.O.
• Zanotto E.D.
• Baesso M.L.

Effects of bioactive agents on dentin mineralization kinetics after dentin bleaching.

Oper Dent. 2020; 45: 286-296

• Gomes M.N.
• Rodrigues F.P.
• Silikas N.
• Francci C.E.

Micro-CT and FE-SEM enamel analyses of calcium-based agent application after bleaching.

Clin Oral Investig. 2018; 22: 961-970

• Barbosa J.G.
• Benetti F.
• de Oliveira Gallinari M.
• et al.

Bleaching gel mixed with MI Paste Plus reduces penetration of H₂O₂ and damage to pulp tissue and maintains bleaching effectiveness.

Clin Oral Investig. 2020; 24: 1299-1309

• Ma Q.
• Chen J.
• Xu X.
• Wang T.

Impact of transparent tray-based application of bioactive glasses desensitizer on the permeability of enamel and dentin to hydrogen peroxide: an in vitro study.

BMC oral health. 2020; 20: 103

• Page M.J.
• McKenzie J.E.
• Bossuyt P.M.
• et al.

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.

BMJ. 2021; 372: n71

CIE Recommendations on uniform color spaces, color-difference equations, psychometric color terms.

Color Res App. 1978; 2: 5-6

• Ouzzani M.
• Hammady H.
• Fedorowicz Z.
• Elmagarmid A.

Rayyan: a web and mobile app for systematic reviews.

Syst Rev. 2016; 5: 210

• Ma J.
• Liu W.
• Hunter A.
• Zhang W.

Performing meta-analysis with incomplete statistical information in clinical trials.

BMC Med Res Methodol. 2008; 8: 56

• Higgins J.P.
• Thomas J.
• Chandler J.
• et al.

Cochrane Handbook for Systematic Reviews of Interventions.

John Wiley & Sons,
2019

• Sterne J.A.C.
• Savović J.
• Page M.J.
• et al.

RoB 2: a revised tool for assessing risk of bias in randomised trials.

BMJ. 2019; 366: l4898

• Guyatt G.
• Oxman A.D.
• Akl E.A.
• et al.

GRADE guidelines, 1: introduction—GRADE evidence profiles and summary of findings tables.

J Clin Epidemiol. 2011; 64: 383-394

• Bommer C.
• Flessa H.P.
• Xu X.
• Kunzelmann K.H.

Hydroxyapatite and self-assembling peptide matrix for non-oxidizing tooth whitening.

J Clin Dent. 2018; 29: 57-63

• Tarique N.
• Awan R.
• Saleh M.I.

Vital tooth bleaching and management of post-operative sensitivity: a clinical trial evaluating the efficacy of different desensitizing materials.

Pak J Med Health Sci. 2017; 11: 1564-1567

• Mohamed H.
• Fayed A.
• Elkassas D.
• Hassanien O.

Impact of using nano-hydroxyapatite on postoperative hypersensitivity of two bleaching techniques–randomized controlled clinical trial.

IOP Conf Series: Mater Sci Engineering. 2021; 1046012004

• Martini E.C.
• Parreiras S.O.
• Szesz A.L.
• Coppla F.M.
• Loguercio A.D.
• Reis A.

Bleaching-induced tooth sensitivity with application of a desensitizing gel before and after in-office bleaching: a triple-blind randomized clinical trial.

Clin Oral Investig. 2020; 24: 385-394

• Pierote JJA
• Prieto L.T.
• Dias C.
• et al.

Effects of desensitizing products on the reduction of pain sensitivity caused by in-office tooth bleaching: a 24-week follow-up.

J Appl Oral Sci. 2020; 28e20190755

Effect of chewing gum on tooth sensitivity following whitening.

Br Dent J. 2010; 208: 571-577

• Pierote JJA
• Barbosa I.F.
• Prieto L.T.
• Lima D.
• Paulillo L.
• Aguiar F.H.B.

Effects of desensitizing dentifrices on the reduction of pain sensitivity caused by in-office dental whitening: a double-blind controlled clinical study.

Clin Cosmet Investig Dent. 2019; 11: 219-226

• Burey A.
• Sutil E.
• Nunez Aldaz M.A.
• et al.

Assessment of the effect of experimental bleaching agent with nano-bioactive material on postoperative sensitivity: a randomized, triple blind clinical trial.

. 2021; 33: 764-774

• Alexandrino L.D.
• Alencar C.M.
• Silveira A.
• Alves E.B.
• Silva C.M.

Randomized clinical trial of the effect of NovaMin and CPP-ACPF in combination with dental bleaching.

J Appl Oral Sci. 2017; 25: 335-340

• Crescente C.L.
• Pinto C.F.

Análise da sensibilidade após o uso prévio de dessensibilizantes em clareamento dental.

Rev Odonto. 2016; 73: 34

• Da Silva R.C.
• De Melo Alencar C.
• Silva B.H.R.
• et al.

A clinical, randomised, double-blind study on the use of nano-hydroxyapatite and arginine during at-home tooth bleaching.

J Clin Diagn Res. 2018; 12: ZC01-ZC05

• Gümüştaş B.
• Dikmen B.

Effectiveness of remineralization agents on the prevention of dental bleaching induced sensitivity: a randomized clinical trial.

Int J Dent Hyg. 2022; 20: 650-657

• Lima T.M.
• França F.M.G.
• Amaral F.L.B.
• Turssi C.P.
• Basting R.T.

The use of desensitizing agents during in-office bleaching might not decrease tooth bleaching sensitivity: a randomized clinical trial.

Int J Esthet Dent. 2022; 17: 100-114

• Loguercio A.D.
• Tay L.Y.
• Herrera D.R.
• Bauer J.
• Reis A.

Effectiveness of nano-calcium phosphate paste on sensitivity during and after bleaching: a randomized clinical trial.

Braz Oral Res. 2015; 29: 1-7

• Maghaireh G.A.
• Alzraikat H.
• Guidoum A.

Assessment of the effect of casein phosphopeptide-amorphous calcium phosphate on postoperative sensitivity associated with in-office vital tooth whitening.

Oper Dent. 2014; 39: 239-247

• Nanjundasetty J.K.
• Ashrafulla M.

Efficacy of desensitizing agents on postoperative sensitivity following an in-office vital tooth bleaching: a randomized controlled clinical trial.

J Conserv Dent. 2016; 19: 207-211

Effect of tri calcium phosphate on efficacy and sensitivity with vital tooth whitening using 20% carbamide peroxide. ClinicalTrials.gov identifier: NCT03026725. Accessed March 4, 2020.

• Pintado-Palomino K.
• Peitl Filho O.
• Zanotto E.D.
• Tirapelli C.

A clinical, randomized, controlled study on the use of desensitizing agents during tooth bleaching.

J Dent. 2015; 43: 1099-1105

Efficacy of MI Paste on bleaching-related sensitivity: randomized clinical trial.

Int J Dent. 2021; 20219963823

• Adil H.M.
• Jouhar R.
• Ahmed M.A.
• et al.

Comparison of casein phosphopeptide with potassium nitrate and sodium monofluorophosphate desensitizing efficacy after in-office vital bleaching: a randomized trial.

Appl Sci. 2021; 11: 9291

• Vochikovski L.
• Favoreto M.W.
• Rezende M.
• et al.

Effect of an experimental desensitizing gel on bleaching induced tooth sensitivity after in-office bleaching: a double-blind randomized controlled trial.

Clin Oral Invest. 2022; 23 (): 1-10

Effect of bioactive glass paste on efficacy and post-operative sensitivity associated with at-home bleaching using 20% carbamide peroxide: a randomized controlled clinical trial.

Eur J Med Res. 2022; 27: 194

• Moharam L.M.
• Khadr S.
• Abdou A.
• Nagi S.M.

Effect of arginine and nano-hydroxyapatite application on the hypersensitivity and color change of bleached enamel: a randomized controlled clinical trial.

J Clin Exp Dent. 2022; 14: 499-505

• Markowitz K.
• Bilotto G.
• Kim S.

Decreasing intradental nerve activity in the cat with potassium and divalent cations.

Arch Oral Biol. 1991; 36: 1-7

The role of selected cations in the desensitization of intradental nerves.

Proc Finn Dent Soc. 1992; 88: 39-54

• Mena-Serrano A.P.
• Parreiras S.O.
• do Nascimento E.M.
• et al.

Effects of the concentration and composition of in-office bleaching gels on hydrogen peroxide penetration into the pulp chamber.

Oper Dent. 2015; 40: E76-82

• Torres C.R.
• Crastechini E.
• Feitosa F.A.
• Pucci C.R.
• Borges A.B.

Influence of pH on the effectiveness of hydrogen peroxide whitening.

Oper Dent. 2014; 39: E261-268

• Balladares L.
• Alegría-Acevedo L.F.
• Montenegro-Arana A.
• et al.

Effects of pH and application technique of in-office bleaching gels on hydrogen peroxide penetration into the pulp chamber.

Oper Dent. 2019; 44: 659-667

• Loguercio A.D.
• Servat F.
• Stanislawczuk R.
• et al.

Effect of acidity of in-office bleaching gels on tooth sensitivity and whitening: a two-center double-blind randomized clinical trial.

Clin Oral Investig. 2017; 21: 2811-2818

The development of the CIE 2000 colour-difference formula: CIEDE2000.

Color Res App. 2001; 26: 340-350

• Pérez Mdel M.
• Ghinea R.
• Rivas M.J.
• et al.

Development of a customized whiteness index for dentistry based on CIELAB color space.

Dent Mater. 2016; 32: 461-467

• Ruiz-López J.
• Perez M.M.
• Lucena C.
• et al.

Visual and instrumental coverage error of two dental shade guides: an in vivo study.

Clin Oral Investig. 2022; 26: 5961-5968

• Paravina R.D.
• Ghinea R.
• Herrera L.J.
• et al.

Color difference thresholds in dentistry.

J Esthet Restor Dent. 2015; 27: 1-9

Casein phosphopeptide amorphous calcium phosphate, a potent desensitizing agent, to reduce postoperative sensitivity after vital tooth bleaching: a systematic review and meta-analysis.

Inter J Scient Res. 2021; 10